49ers-Seahawks Injury Report: RB Christian McCaffrey questionable, RB Jordan James, & WR Jordan Watkins doubtful for week 1 matchup

The 49ers have released their injury report, with 3 players on it.

Questionable:

RB Christian McCaffrey (Calf)

Doubtful:

RB Jordan James (Finger)

WR Jordan Watkins (Ankle)

With Watkins doubtful, the 49ers will likely elevate wide receiver Russell Gage Jr., to go along with Jauan Jennings, Ricky Pearsall, Skyy Moore, & Marquez Valdes-Scantling.

If McCaffrey can’t go, & since James is doubtful then the 49ers would have to elevate running back Sincere McCormick for week 1, but hopefully they won’t have to, we should know tomorrow by 4pm eastern/1pm pacific time.

#49ers practice report for Week 1 vs. SEA
Doubtful
WR Jordan Watkins (ankle)
RB Jordan James (finger)

Questionable
RB Christian McCaffrey (calf)

— Jennifer Lee Chan -all platforms: @jenniferleechan (@jenniferleechan) September 5, 2025

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About Author

Jason Hurley

Die Hard 49ers fan from New York, been covering the 49ers salary cap since 2005, with several different websites, including NinersNation.com, & the now defunct NinerCapHell, I have a track record of being as accurate as possible, I try to be as thorough as possible, and you can find me on X/Twitter @49erscap, & on Blue Sky App @49erscap.bsky.social.

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